Ahmed Osman

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: AUTOPHAGY. 2023;19(7):1952-1981

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy.

Beccari S; Sierra-Torre V; Valero J; Pereira-Iglesias M; García-Zaballa M; Soria FN; De Las Heras-Garcia L; Carretero-Guillen A; Capetillo-Zarate E; Domercq M; Huguet PR; Ramonet D; Osman A; Han W; Dominguez C; Faust TE; Touzani O; Pampliega O; Boya P; Schafer D; Mariño G; Canet-Soulas E; Blomgren K; Plaza-Zabala A; Sierra A
Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020

ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.

Stratoulias V; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodríguez-Moreno A; Murgoci A-N; García-Domínguez I; Alonso-Bellido I; González Ibáñez F; Picard K; Vázquez-Cabrera G; Posada-Pérez M; Vernoux N; Tejera D; Grabert K; Cheray M; González-Rodríguez P; Pérez-Villegas EM; Martínez-Gallego I; Lastra-Romero A; Brodin D; Avila-Cariño J; Cao Y; Airavaara M; Uhlén P; Heneka MT; Tremblay M-È; Blomgren K; Venero JL; Joseph B
Article: CLINICAL CANCER RESEARCH. 2023;29(4):775-783

Dynamic Mutational Landscape of Cerebrospinal Fluid Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases.

Wijetunga NA; Goglia AG; Weinhold N; Berger MF; Cislo M; Higginson DS; Chabot K; Osman AM; Schaff L; Pentsova E; Miller AM; Powell SN; Boire A; Yang JT
Article: FRONTIERS IN ONCOLOGY. 2023;13:1202200

Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation.

Zisiadis GA; Alevyzaki A; Nicola E; Rodrigues CFD; Blomgren K; Osman AM
Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_7):vii248-vii249

RBIO-08. MEMANTINE INCREASES DENDRITIC ARBORIZATION OF IMMATURE NEURONS AFTER IRRADIATION WITH NO EVIDENCE OF DISRUPTION IN THE NORMAL BRAIN FUNCTION

Zisiadis GA; Rodrigues C; Pizzirusso G; Arroyo-García L; Osman A; Blomgren K
Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_1):i192

LTBK-06. Memantine increases dendritic arborization and integration of immature neurons after cranial irradiation

Zisiadis G; Rodrigues C; Pizzirusso G; Arroyo-García L; Osman A; Blomgren K
Article: STEM CELL REPORTS. 2022;17(5):1089-1104

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.

Muhl L; He L; Sun Y; Andaloussi Mäe M; Pietilä R; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Hansson EM; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20

An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion.

Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: SCIENTIFIC REPORTS. 2020;10(1):12369

Cranial irradiation at early postnatal age impairs stroke-induced neural stem/progenitor cell response in the adult brain.

Neumann S; Porritt MJ; Osman AM; Kuhn HG
Article: CELL REPORTS. 2020;31(9):107699

Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain.

Osman AM; Sun Y; Burns TC; He L; Kee N; Oliva-Vilarnau N; Alevyzaki A; Zhou K; Louhivuori L; Uhlén P; Hedlund E; Betsholtz C; Lauschke VM; Kele J; Blomgren K
Article: NEUROSCIENCE. 2019;405:92-102

The Secretome of Microglia Regulate Neural Stem Cell Function.

Osman AM; Rodhe J; Shen X; Dominguez CA; Joseph B; Blomgren K
Article: NEUROSCIENCE. 2018;384:314-328

Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke.

Karlsson L; González-Alvarado MN; Larrosa-Flor M; Osman A; Börjesson M; Blomgren K; Kuhn HG
Article: ONCOIMMUNOLOGY. 2018;7(2):e1382790

Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype.

Saidi D; Cheray M; Osman AM; Stratoulias V; Lindberg OR; Shen X; Blomgren K; Joseph B
Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.

Shen X; Burguillos MA; Osman AM; Frijhoff J; Carrillo-Jiménez A; Kanatani S; Augsten M; Saidi D; Rodhe J; Kavanagh E; Rongvaux A; Rraklli V; Nyman U; Holmberg J; Östman A; Flavell RA; Barragan A; Venero JL; Blomgren K; Joseph B
Article: ONCOTARGET. 2016;7(3):2239-2248

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice.

Osman AM; Neumann S; Kuhn HG; Blomgren K
Article: GLIA. 2015;63(12):2220-2230

Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia.

Umekawa T; Osman AM; Han W; Ikeda T; Blomgren K
Article: CELL REPORTS. 2015;10(9):1626-1638

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

Burguillos MA; Svensson M; Schulte T; Boza-Serrano A; Garcia-Quintanilla A; Kavanagh E; Santiago M; Viceconte N; Oliva-Martin MJ; Osman AM; Salomonsson E; Amar L; Persson A; Blomgren K; Achour A; Englund E; Leffler H; Venero JL; Joseph B; Deierborg T
Article: CELL TRANSPLANTATION. 2014;23(12):1657-1671

Transplantation of enteric neural stem/progenitor cells into the irradiated young mouse hippocampus.

Osman AM; Zhou K; Zhu C; Blomgren K
Article: GLIA. 2013;61(5):790-799

Radixin expression in microglia after cortical stroke lesion.

Persson Å; Osman A; Bolouri H; Mallard C; Kuhn HG
Article: BRAIN RESEARCH. 2013;1503:62-77

Selective expression of hyaluronan and receptor for hyaluronan mediated motility (Rhamm) in the adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.

Lindwall C; Olsson M; Osman AM; Kuhn HG; Curtis MA
Article: STROKE. 2011;42(12):3559-3565

Long-term stimulation of neural progenitor cell migration after cortical ischemia in mice.

Osman AM; Porritt MJ; Nilsson M; Kuhn HG
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Alla övriga publikationer

Preprint: BIORXIV. 2023;BIORXIV

Leptomeningeal anti-tumor immunity follows unique signaling principles.

Remsik J; Tong X; Kunes RZ; Li MJ; Osman A; Chabot K; Sener UT; Wilcox JA; Isakov D; Snyder J; Bale TA; Chaligné R; Pe'er D; Boire A
Conference publication: GLIA. 2023;71:E512

ARG1 expression in basal forebrain microglia modulates hippocampal innervation and cognition during postnatal development

Venero JL; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodriguez-Moreno A; Murgoci A-N; Garcia-Dominguez I; Alonso-Bellido I; Ibanez FG; Picard K; Vazquez-Cabrera G; Posada-Perez M; Vernoux N; Tejera D; Grabert K; Cheray M; Gonzalez-Rodriguez P; Perez-Villegas EM; Martinez-Gallego I; Lastra-Romero A; Brodin D; Avila-Carino J; Cao Y; Airavaara M; Uhlen P; Heneka MT; Tremblay M-E; Blomgren K; Stratoulias V; Joseph B
Conference publication: BRAIN TUMOR RESEARCH AND TREATMENT. 2022;10(Suppl):s397-s391

Irradiation causes a biphasic inflammatory response in the juvenile mouse brain

Romero AL; Osman A; Blomgren K
Conference publication: NEURO-ONCOLOGY. 2022;24:248-249

MEMANTINE INCREASES DENDRITIC ARBORIZATION OF IMMATURE NEURONS AFTER IRRADIATION WITH NO EVIDENCE OF DISRUPTION IN THE NORMAL BRAIN FUNCTION

Zisiadis GA; Rodrigues C; Pizzirusso G; Arroyo-Garcia L; Osman A; Blomgren K
Conference publication: NEURO-ONCOLOGY. 2022;24:192

MEMANTINE INCREASES DENDRITIC ARBORIZATION AND INTEGRATION OF IMMATURE NEURONS AFTER CRANIAL IRRADIATION

Zisiadis G; Rodrigues C; Pizzirusso G; Arroyo-Garcia L; Osman A; Blomgren K
Preprint: BIORXIV. 2021

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

Beccari S; Sierra-Torre V; Valero J; García-Zaballa M; Carretero-Guillen A; Capetillo-Zarate E; Domercq M; Huguet P; Ramonet D; Osman A; Han W; Dominguez C; Faust T; Touzani O; Boya P; Schafer D; Mariño G; Canet-Soulas E; Blomgren K; Plaza-Zabala A; Sierra A
Preprint: BIORXIV. 2021

Arg1⁺ microglia are critical for shaping cognition in female mice

Stratoulias V; Ruiz R; Kanatani S; Osman A; Armengol J; Rodríguez-Moreno A; Murgoci A-N; García-Domínguez I; Keane L; Vázquez-Cabrera G; Alonso-Bellido I; Vernoux N; Tejera D; Grabert K; Cheray M; González-Rodríguez P; Pérez-Villegas E; Martinez-Gallego I; Brodin D; Avila-Cariño J; Airavaara M; Uhlén P; Heneka M; Tremblay M-È; Blomgren K; Venero J; Joseph B
Preprint: BIORXIV. 2020

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

He L; Mäe MA; Muhl L; Sun Y; Pietilä R; Nahar K; Liébanas EV; Fagerlund MJ; Oldner A; Oldner A; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Mirabeau O; Hansson E; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Arnold T; Alitalo K; Eriksson L; Lendahl U; Betsholtz C
Conference publication: GLIA. 2017;65:E330

Ischemia/stroke rapidly impairs microglial phagocytosis in vivo

Galeano MSB; Umekawa T; Osman A; Han W; Dominguez C; Blomgren K; Sierra A
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2017;142:38-39

Neural progenitor migration in the adult brain under physiological and pathological conditions

Kuhn G; Motalleb R; Osman A; Berns E; Stupp S
Thesis / dissertation: 2015

Brain repair after irradiation or ischemia : role of neural stem cells and microglia

Osman, Ahmed

Anställningar

Biträdande Lektor, Kvinnors och barns hälsa, Karolinska Institutet, 2020-2026

Examina och utbildning

Medicine Doktorsexamen, Institutionen för kvinnors och barns hälsa, Karolinska Institutet, 2015

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Examina och utbildning

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